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The meta-analysis by Tuersun found no significant difference in body weight reduction when comparing the combination therapy to either GLP-1RA monotherapy or SGLT2i monotherapy: this finding challenges the assumption of a synergistic or additive effect on weight loss [15]
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The drugs could produce huge benefits for people with obesity but also present a major cost challenge given the large percentage of the population that is eligible for them, the report said
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