In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity, thereby protecting the cells from reactive oxygen species and the products of peroxidation
The initiation of ferroptosis is deeply integrated with amino acid metabolism (glutamate/cystine balance), lipid metabolism (PUFA availability) and metal homeostasis (iron regulation)
& Kochetkov, S
Grandjean J, Schroeter A, Batata I, Rudin M
Hair biology is the second major area of research interest, and it's more mechanistically indirect than the skin data
Figure 2 VD increases several neutrophins, such as nerve growth factor, glial cell-derived neurotrophic factor, brain-derived neurotrophic factor, neurotrophin-3, ciliary neurotrophic factor, low-affinity p75 neurotrophin receptor, and transforming growth factor-b2, and down-regulates neurotrophin 4