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Increased intestinal permeability in patients with Crohn's disease and their relatives

Initially, NOX2 activation generates significant quantities of H 2 O 2 /O, which subsequently activate key signaling pathways such as MAPK and JNK, leading to nuclear membrane breakdown and chromatin decondensation, culminating in NET formation

R.LiX.et al (2012)

E., Ryan, B

Operates below conscious perception