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Taken together, these pooled safety analyses (119123) and CV outcome safety trials (124127), together with review of published data from numerous clinical trials (39), provide reassuring evidence that the catalytic activity of the DPP-4 molecule can be modulated to enhance the beneficial metabolic effects of its substrates (such as the incretin hormones) without adversely affecting any of the protease-independent metabolic effects discussed above, or interfering with any of its other (non-metabolic) functions
Alternatively, a number of clinical trials have been conducted in the recent past to examine the radiomodulating effect of selenium in general for improving the quality of life of cancer patients undergoing radiotherapy [95,96,97,98,99]
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