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388 In a placebo-controlled trial in 51 hospitalized patients with major depression, the addition of 300 mg B1 per day to antidepressant therapy led to faster symptom reduction
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But there is a trade-off: DAC also increases the potential for side effects (more on that below)
7,8 Tumor heterogeneity, both spatial and temporal, adds another layer of complexity, as subclonal populations with distinct genetic and epigenetic features coexist and evolve under selective therapeutic pressure
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