The published trial data reflects ideal conditions (free medication, close monitoring, motivated participants)
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In rare cases, certain supplements (such as botanical extracts or protein powders) can develop microbial growth, especially in humid climates, and thus pose additional hazards
Garca-Ruiz C, Colell A, Morales A, Kaplowitz N, and Fernndez-Checa JC (1995)
The methods were prepared using the Cochrane Handbook and Review Manager (RevMan) version 5.4 software (The Nordic Cochrane Centre, The Cochrane Collaboration, 2020, Copenhagen, Denmark) and this paper was reported using the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement [4448]