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Further analyses of iron ion levels and the lipid peroxidation markers GSH and MDA revealed that Fe 2+ and MDA levels were significantly higher following PE treatment relative to levels in control cells, while GSH levels were significantly reduced, and PQQ treatment significantly reversed all three of these PE-induced changes (Figures 4BD)

Those who received the NAC saw an overall improvement compared to those who were given a placebo

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We found expression of e2f1 upregulated similarly to that of gpx4 upon A2ARi or H89 treatment by qPCR analysis (Figure 6, F and G)