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The fraction of intact sermorelin that reaches systemic circulation through this route is not consistent across patients, is not validated in controlled clinical trials for adult GH optimization, and is not comparable to what subcutaneous injection achieves in terms of IGF-1 response
We also know that high levels of human growth hormone over a long period can produce irreversible acromegaly, the complications of which include arthritis, sleep apnoea, diabetes, high blood pressure, heart disease and often premature death
Conclusion Compounded GLP-1 therapies are likely to remain part of clinical practice as long as shortages, affordability challenges, and growing patient demand continue
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