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NAC improved both motor and non-motor symptoms and significantly increased GSH/GSSG ratios, GSH levels in the CSF, and DAT binding
However, in chronic tendinopathy, its efficacy may be compromised due to persistent inflammation, tissue degeneration, fibrosis, and abnormal ECM composition, which can impede IGF-1 diffusion and diminish the responsiveness of tendon cells (Tang et al., 2024)
Costell M, Mguez MP, OConnor JE, et al
Mehta, A., & Marso, S
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