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The gut-derived incretin hormone glucagon-like peptide 1 (GLP-1) is secreted upon meal ingestion and controls glucose metabolism by modulating pancreatic islet cell function, food intake and gastrointestinal motility, amongst other effects

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Engineering of gasdermin D-cleaving proteases Although the evolved X(GD_L) proteases displayed promising activity through profiling activity in the PACE architecture, they failed to yield measurable kinetic parameters or substrate cleavage in mammalian cells, likely due to insufficient catalytic activity (Fig

Like GLP-1, OXM is rapidly degraded in the circulation by DPP-IV

At the end of the study, these participants' BMIs were maintained at 34.0 kg/m2

These include alcohol, opioids, and nicotine (and, anecdotally, online gambling, skin-picking, excessive shopping, and other non-substance related compulsive behaviors)