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lipid metabolism is reduced and NAD + generation is impaired 37

The GIP-based backbone carries non-coded Aib residues at positions 2 and 20 (studied for DPP-4 resistance), an alpha-methyl-leucine modification near position 13, and a C20 fatty-diacid group attached via a gamma-glutamate/AEEA linker that has been examined for albumin binding and extended in-vitro half-life

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