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Glucagon-like Peptide-1 (GLP-1) is a hormone that helps regulate blood sugar levels and appetite

Both the android-to-gynoid fat ratio and trunk-to-leg fat ratio were significantly reduced in the 8mg group, indicating that retatrutide preferentially targets the most metabolically harmful fat deposits

For example, Metformin is notorious for causing nausea, bloating, and diarrhea

For type 2 diabetes, NICE guidance (NG28) recommends GLP-1 RAs based on individual factors including comorbidities, prior treatments, and HbA1c targets

However, another study found that individuals who took the weight-loss drug Orlistat in addition to carnitine supplements for 1 year lost an average of 4 pounds more than those on a regimen of Orlistat alone

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