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Long-term safety data remains limited for most of these compounds, so risks beyond short trials or animal studies are largely unknown
This effect is thought to be mediated through GLP-1 receptors in the cardiovascular system and is generally not clinically significant, though patients with certain arrhythmias or those sensitive to heart rate changes should be monitored
At week 52, participants that were treated with tirzepatide were not a higher risk of cardiovascular risk than those who were treated with insulin Glargine, metformin, and other glucose-lowering medications
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95% CI 0.25 to 1.34) (Fig
Thats because Wegovy (the brand name for the drug semaglutide thats been FDA-approved for weight management) is a peptide a small protein thats a synthetic version of the hormone GLP-1
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