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Conclusion/ This study suggests that GSH deficiency is associated with several defects linked to premature aging in HIV patients, and provides proof-of-concept that supplementing GlyNAC improves multiple key defects associated with premature aging in PWH including GSH deficiency, oxidative stress, impaired mitochondrial fuel oxidation, elevated inflammation, endothelial dysfunction, insulin resistance, genomic damage, strength, and cognitive defects
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