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27 , 461469.e466 (2018)

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42 Metformin interferes with oxidative phosphorylation in mitochondria and stimulates osteogenic differentiation via AMPK, which is known to promote osteogenic and suppress adipogenic differentiation, although the exact mechanism of this action is unknown

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NMNH is dephosphorylated into NRH to be transported into the cell through equilibrative nucleoside transporters (ENTs) 35 , where it is phosphorylated back into NMNH by adenosine kinase (AK) 36