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Plus, it decreases the caspase-dependent apoptosis (a programmed cell death process) associated with aging [11]

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Furthermore, it is a powerful antioxidant, boosts the skins immunity against pathogenic organisms, acts as an anti-aging agent, helps treat skin issues like hyperpigmentation, and detoxifies skin-cell damaging pollutants and toxins

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For instance, a population of macrophages with high levels of SPP1 transcripts has been identified in tumors from patients with advanced metastatic castration-resistant prostate cancer (mCRPC), which suppressed CD8 + T-cell activity and promoted PD-1 resistance [182]