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The host and gut microbes exist in a symbiotic relationship, in which the host creates a nutrient-rich environment for microbes, and the microbes, in turn, impact host physiology, immunology, and metabolism 239

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Glucagon is classically viewed as a fasting and counter-regulatory hormone that increases hepatic glucose output through glycogenolysis and gluconeogenesis

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PubMed Central , StatPearls , StatPearls Publishing, 2026

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Safety was assessed in all participants exposed to at least one dose of the trial product

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Short-chain fatty acids, particularly butyrate and propionate, have been shown to activate receptors on enteroendocrine L-cells, triggering GLP-1 release

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