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Ultrastructural analysis using high-resolution electron microscopy has identified approximately 20 nm as the biophysical optimum for efficient transfer ( 2+ creates microdomains that facilitate the activation of mtCU ( 2+ enters the mitochondrial matrix, it acts as a critical regulator of the Krebs cycle

Challenges in predicting and optimizing multireceptor agonism Predicting in vivo efficacy of multi-receptor agonists remains a major unresolved challenge, as the pharmacologic activity depends not only on receptor affinity but also on tissue-specific receptor density, distribution, and internalization kinetics

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Prausmller S, Weidenhammer A, Heitzinger G et al (2023) Obesity in heart failure with preserved ejection fraction with and without diabetes: risk factor or innocent bystander

Rights and permissions About this article Cite this article Sanchis-Gomar, F., Neeland, I.J