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Richard Wright, MD, board-certified cardiologist at Providence Saint Johns Health Center in Santa Monica, CA, not involved in this research, commented on the trial results for Medical News Today
The incidence of these complications has risen dramatically in the 2000s but is expected to decline over the next 20 years
We found that, of the 12 GLP-1 [drugs] identified by our search, the greatest mean body weight reduction was reported in randomized controlled trials of retatrutide, tirzepatide, and semaglutide, the researchers wrote in their paper, published Tuesday in the Annals of Internal Medicine
This was associated with a reduction in macrophage infiltration, lower expression of IL-1 and IL-6, and an increase in IL-10 in the heart (41)
The research demonstrated that CD4+ T cells are responsible for neurodegeneration, as CD4+ T lymphocytes have been found as key mediators in dopaminergic neuronal death in the MPTP mouse model of PD (66)
& Romero, R
