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Upregulation of macrophage migration inhibitory factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammation

Any references to migration, angiogenesis, or tissue-related pathways are provided only for research context and do not imply therapeutic or clinical use

Injectable administration is hypothesized to provide systemic distribution, but human pharmacokinetic data for this route does not exist

First, phase II clinical trials evaluating MOTS-c in type 2 diabetes and sarcopenia are in development, and their results will provide the first randomized controlled evidence in humans to define therapeutic doses with statistical rigor

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