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If you are considering berberine because you cannot access a GLP-1 drug, use the right expectations: it may help a little, it may upset your gut, and it can interact with medications

Zuckerman SH, Shellhaas J, Butler LD

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154,155,156 MRPs preferentially export drugglutathione conjugates and promote drug sequestration into perinuclear vesicles, thereby restricting intracellular and nuclear drug availability

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