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2 HS is frequently associated with comorbidities such as obesity, diabetes, and metabolic syndrome 3 , which can exacerbate systemic inflammation
Growth factors and cell migration: The peptide boosts growth factor levels (such as fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF)) and increases cell adhesion proteins (integrins)
Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis
Medicines to help with nausea, such as ondansetron, or treatments for constipation or diarrhea may be used when needed
In one study, people lost up to 21% of their body weight at 88 weeks
New England Journal of Medicine (2025) 2
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