Acknowledgements We sincerely appreciate the thoughtful and constructive comments provided by the editor and reviewers, which have greatly improved the clarity and overall quality of this manuscript
While most common variants have a modest effect size, rare coding variants identified through large-scale sequencing efforts often exhibit stronger effects and, in some cases, offer direct insight into disease mechanisms
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that is, cleavage activity on single-residue substitutions is predictive of cleavage activity on combinations of those substitutions (Supplementary Fig
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Benefits Excellent for pigmentation and blemish care Packed with glutathione and vitamins to brighten the skin from within with a 4-step whitening effect Key Ingredients Glutathione : Brightens skin & evens tone Tranexamic Acid : Helps reduce dark spots & discoloration 5% Niacinamide : Brightens & improves uneven skin tone Vitamin C & Derivatives : Enhances radiance & skin clarity Vitamin E : Nourishes & protects skin Coenzyme Q10 : Improves skin elasticity & vitality Research Results Hyperpigmentation reduced by 8.04% Inner skin discoloration reduced by 51.22% Skin tone evenness improved by 15.07% Item 2656179 Apply the product to the skin, remove the support after 10--20 minutes, and spread the remaining essence evenly