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These effects are typically dose-dependent, most prominent during dose escalation, and tend to diminish over time

The Single-Lab Problem Predrag Sikiric is a professor of pharmacology at the University of Zagreb

Accessed 3/10/2016

In line with these results, in the randomised, placebo-controlled SUSTAIN 5 trial of once-weekly subcutaneous semaglutide as an add-on to basal insulin, the insulin dose was significantly decreased from baseline with both the semaglutide 0.5 and 1.0 mg doses compared with placebo [38]

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