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Moreover, PCR data showed that Nrf2 downregulation increased the expression of IL-6, iNOS, MMP13, and p16 in the chondrocytes treated with metformin (Fig
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However, a Herxheimer reaction can last days to weeks for some individuals
Inflammatory mechanisms may play a crucial role in BD pathophysiology via their regulation of synaptic transmission/plasticity and neuronal survival [67, 68]
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