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Patients treated with arGLP-1 achieved a median weight loss of 11.7 kg, an increase in %TWL of 8.9% and 25.5% in %EWL, respectively, after 1 year of therapy
8285 Nevertheless, the optimal targeting of specific PDE isoforms across tissues remains uncertain
It reached Phase II clinical trials for postoperative ileus (a gut-recovery condition) and was discontinued after the trial did not show efficacy
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Retatrutide (Eli Lilly) and CagriSema (Novo Nordisk) represent different approaches to the same goal: achieving weight loss approaching bariatric surgery without the scalpel
Several caveats deserve emphasis
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