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Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues
The median Cmax in this study is significantly lower than that considered therapeutic for preventing organ transplant rejection in humans, where a blood concentration of 8-15 ng/ml is often desired.[14, 53] This is intentional, as our goal was to use a dose that results in measurable blood concentrations, but not with the objective of causing immunosuppression
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