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Considering that PSC activation is a key factor in pancreatic fibrosis, we speculated that excess ROS production induced by high glucose may induce PSC activation in vivo

The powder may have degraded before reconstitution, or the water temperature was too extreme

The shuttle involves two different glycerol-3-phosphate dehydrogenases: one is cytosolic (GPD1), acting to produce glycerol-3-phosphate, and one is an integral protein (GPD2) of the inner mitochondrial membrane that acts to oxidize the glycerol-3-phosphate produced by the cytosolic enzyme

Curr Opin Endocrinol Diabetes Obes (2013) 20(2):8797