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Further studies assessing the temporal relation between glucose control, weight loss, and dermatologic improvement following initiation of GLP-1RAs are needed to determine the efficacy of GLP-1RAs and the mechanism by which they act
If cholelithiasis is suspected, gallbladder studies and appropriate clinical follow-up are indicated Hypoglycemia: Adult patients with type 2 diabetes on an insulin secretagogue (eg, a sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia with use of Saxenda
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Chronic treatment with the co-agonist also improved glucose tolerance and insulin secretion in cynomolgus monkeys and humans [91]
More pathways do not equal more evidence No controlled human trial has tested this three-compound combination
Medical nutrition therapy interventions provided by dietitians for adult overweight and obesity management: an academy of nutrition and dietetics Evidence-Based practice guideline
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