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J Epithel Biol Pharmacol

IGF-1 is a small peptide that circulates in plasma with the majority (98%) bound to the IGF-binding proteins (IGFBP)

Weight loss reduces the risk of these conditions, contributing to overall pain relief

Potential side effects include injection site reactions (redness, swelling, pain), mild nausea (rare), headache (uncommon), fatigue (rare)

2017 Mar;17:57-66

Conversely, mutations in genes involved in methionine metabolism, dysregulated methionine metabolism, and abnormal hydrogen-sulfide and glutathione levels have all been implicated in neurodegenerative disease and in aging more generally (Paul, 2021