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The phenyl ring of F23 Cagri forms extensive van der Waals contact with L16 Cagri , Y149 1.40 , Y146 1.37 (superscript numbers for receptor residues refer to the class B1 GPCR numbering scheme 17 ), anchoring the peptide segment with the CTR transmembrane (TM) bundle level with the micelle interface

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Interestingly, clinical studies in patients with neurodegenerative diseases (NDD) who do not suffer from diabetes mellitus have shown the neuroprotective effect of GLP-1RAs, independent of blood glucose levels [31]