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Samples were separated using a Raptor HILIC-Si 2.1 100 mm, 2.7 m LC column (Restek) with a constant flow rate of 400 l/min following a flow gradient starting at 5% Mobile Phase B (H 2 O + 5 mM AmFm +0.5% formic acid) then going up to 40% in 5 min, which was followed by re-equilibration at 5% B for 4 min and 30s
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16 Based on these data, it is reasonable to decrease background prandial insulin doses by 50%, or even hold the prandial insulin altogether in patients with good glucose control or a history of hypoglycemia when starting a GLP-1 RA
Im not going to tell you what to do about that gap between optimal therapy and available therapy, but I will tell you to make informed decisions with your eyes wide open about what the actual clinical data shows
& Biessmann, H
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