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The effects on GLP-1 levels are often subtle and may not translate into significant clinical benefits for weight loss or diabetes management

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Karim Gebara, Lionel Moulis, Joana Pissarra, Benjamin Rivire, Georges-Philippe Pageaux, Jos Ursic-Bedoya Clinics and Research in Hepatology and Gastroenterology .2025

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Extensive preclinical and clinical researches have demonstrated that GLP-1RAs exert beneficial effects on various aspects of cardiovascular health

The exact mechanism of berberine on glucose metabolism is still being investigated