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This feature renders cancer cells more sensitive to external stimuli that further increase the production of ROS 145,146,147 , and, as schematically summarized in Table 1, an increasing number of therapeutic strategies are being developed to elevate ROS levels to overwhelm the redox adaptation of the same cells, inducing oxidative stress incompatible with cellular life 148,149,150,151 (Fig
doi: 10.1038/nature11209 21 HettaHFRamadanYNAlharbiAAAlsharefSAlkindyTTAlkhamaliAet al
Although most individuals with G6PD variant alleles are asymptomatic with no detectable hemolysis at baseline, RBCs do accumulate oxidative damage at an accelerated rate over time 11
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