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It says a rising TSH during GLP-1 therapy may indicate the thyroid replacement dose needs adjustment rather than that the GLP-1 has failed

All MS and MS/MS data for protein samples were processed with the Proteome Discoverer software (Thermo Scientific, version 2.1) coupled to an in-house Mascot search engine (Matrix Science, version 2.5.1)

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The therapy is delivered through weekly injections and has been widely used in the treatment of Type 2 Diabetes, as well as a clinically supported tool for weight management alongside proper nutrition, exercise, and sleep

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Its half-life in preclinical models is roughly 2 hours, longer than sermorelin, because the D-amino acids and C-terminal amide block proteolytic degradation