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The GLP-1 receptors may already be partially desensitized from semaglutide use, but the GIP receptors are "fresh" and fully responsive

But efficacy data from trials reflects population averages individual responses vary significantly, and there are multiple valid reasons to make this change

[53] [54] This is because it requires significant damage to the liver to impair bilirubin excretion, hence minor impairment (in the absence of biliary obstruction or Gilbert syndrome) would not lead to jaundice

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That 4-percentage-point difference may sound modest, but in clinical weight management, it's substantial, and it held up across every time point measured (3, 6, 9, and 12 months into treatment)