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In many diabetes cardiovascular outcome trials, average weight loss was relatively modest, yet the reduction in cardiovascular events was meaningful, suggesting additional biology at play beyond lighter body, healthier heart. 2) The timeline doesnt always match weight loss explains it all. Weight loss is a gradual process, but cardiovascular risk reduction can begin earlier than youd expect if weight loss were the only driver

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Consistent with this, TeNT-mediated silencing of LS GLP-1R neurons markedly increased the consumption of palatable food but not standard chow (Figure 3, C and D)