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[4] [6] However, for some patients, persistent nausea can significantly impact quality of life and treatment adherence

But it is not statistically different from the placebo group, which means tirzepatide itself may not be the direct cause

PLoS ONE 7 , e51898 (2012)

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Key points Available as a twice-daily or weekly injection Used less often today due to newer options with better convenience Oral GLP-1 Medicines: A New Direction One of the biggest challenges with GLP-1 therapy has been injections

Study Limitations and Future Research Directions The interpretation of the findings is limited by the small GLP-1RA cohort (n = 12), baseline imbalances in BMI and sex, the single-center retrospective design, incomplete autoantibody testing, and a median follow-up of approximately eight months