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Activation of GLP-1R also triggers the PI3K/Akt signaling pathway via the subunits of G proteins, thereby promoting -cell viability and replicative capacity ( 2.2 Inflammation and immune modulation Recent preclinical studies have demonstrated its bidirectional immunomodulatory effects, including improvement of organ dysfunction, regulation of immune responses, and mitigation of sepsis-associated cytokine storms, mediated through anti-inflammatory and anti-apoptotic pathways
(2024) 103:e40364
Nat Microbiol 2021;6:1367-82
Most of these sites are located at or next to the important functional sites and domains, which might affect the structure and function of proteins, reflecting their key role in the adaptation to hypoxia
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This cleavage event initiates the release of the encapsulated antimicrobial payload, ensuring activation only in the presence of pathogenic microorganisms
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