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Sequence alignment and percentage of similarities were derived using ClustalW v2.1 19 available on the website of EMBL

To understand why these are not GLP-1 requires some unpacking of what GLP-1 medicines are: they are pharmaceutical products, requiring specific licences to sell, and work by mimicking the bodys naturally occurring glucagon-like peptide-1 hormone

The agents used included liraglutide, semaglutide, tirzepatide, and other GLP-1RAs

Convenience has value when users still receive safety checks and escalation instructions

[1] [3] In the pivotal clinical trials (SURPASS program for diabetes and SURMOUNT program for weight management), erectile dysfunction was not identified as a common adverse event, though it's important to note that sexual function was not systematically assessed as a prespecified endpoint in these studies

Human evidence is limited