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Analysis of the microbial composition revealed that metformin treatment increased the abundance of Firmicutes and decreased the abundances of Actinobacteria and Proteobacteria at the phylum level (Fig
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For example, tissue-resident pancreatic stellate cell-derived cancer-associated fibroblasts (CAFs) secrete lipids, such as lysophosphatidylcholines, which promote the absorption and synthesis of phosphatidylcholine by cancer cells [28]
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