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Both GCGR and GLP-1R are necessary for the full effect of G49 in body weight loss and BAT activation We next performed experiments aimed to identify the relative contribution of GCGR and GLP-1R to the rapid responses of G49 mediated by the inter-organ crosstalk that favors EE through BAT/beiging activation

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An unexpected relationship

Recent evidence shows that individuals with specific genetic variants in the GLP-1 receptor pathway (such as GLP1R rs6923761) may have different metabolic responses to treatment, suggesting that personalized assessment before ordering can optimize selection