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For bloating and distension, a large meta-analysis of 82 trials found combination probiotics and Bacillus strains showed benefit, though the authors rated the overall certainty of evidence as low, so this is best framed as "some evidence," not a guarantee

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By incorporating fiber-rich foods into your diet, you can enhance the medications effects, making it easier to adhere to a healthier, calorie-restricted eating plan without feeling deprived

There are also concerns the drug may increase the risk of skin cancer in the form of melanoma, according to the New Zealand Dermatological Society