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Concurrently, GLP-1 stimulates the translocation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) into the nucleus via the PKA/ERK signaling pathway, where Nrf2 induces transcription of genes for SOD, GPx, catalase, thioredoxin, and other antioxidant enzymes, further enhancing the cellular antioxidant defense system

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doi: 10.1038/ng.2982 33 ChmurzynskaASeremak-MrozikiewiczAMalinowskaAMRozyckaARadziejewskaASzwengielAet al

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44 However, a cohort study of 892 participants found that plasma TMAO levels were negatively associated with T2DM risk