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These medications work primarily through pancreatic and central nervous system pathways

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Once in the body, vitamin B12 is used in several essential processes

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In addition, DPP-4 cleaved GLP-1(7-36)amide and GLP-1(7-37) to form GLP-1(9-36)amide or GLP-1(9-37), low-affinity ligand of GLP-1 receptor and nonprimary role in regulating glucose metabolism (98101)