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Exendin-4 significantly increased insulin level and phosphorylation of insulin receptor substrate 1 (IRS-1) in rat hippocampus, and could not change the status of tau phosphorylation without insulin in HT22 neurons, suggesting that insulin is required in reduction of tau hyperphosphorylation by GLP-1R agonists (154)

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DAndrea Meira I, Romo TT, Pires do Prado HJ, Krger LT, Pires MEP, da Conceio PO (2019) Ketogenic diet and epilepsy: what we know so far