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JAMA 330 , 14721483 (2023)

Dosing and Titration Both medications start at a low dose and increase gradually (titrate) over weeks to months to reduce GI side effects

Lose 10 pounds of muscle over several months of treatment, and your body now burns 60 fewer calories per day than it would have otherwise

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Here is the most important takeaway: As of late 2025, there are no FDA-approved GLP-1 medication patches (semaglutide, tirzepatide, or others) commercially available from a legitimate pharmacy

As a dieting aid, doctors usually recommend GLP-1 medications for adults who have a body mass index (BMI) of 30 or above, which falls in the obesity range