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These therapies need better evidence, clearer standards, responsible prescribing, and meaningful adverse-event reporting

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Caution: Peptide therapies must always be done under qualified medical supervision and guidance

Based on KFF analysis of Medicare data from 2020, an estimated 7% of Medicare beneficiaries, or 3.6 million overall, had established cardiovascular disease and obesity or overweight in 2020, and so could be eligible for Medicare coverage of Wegovy for its new indication (Figure 1) (see Methods for details)

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Because of the cardiorenal benefits of RAASis, if these medications must be temporarily reduced or withheld due to hyperkalemia, a retrial of RAASi should be considered, potentially at a lower dose once hyperkalemia is resolved