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Graphical Abstract Keywords: astrocytes, ependymal cells, Alzheimer's disease, streptozotocin, semaglutide Introduction The combination of reactive and degenerative changes in astrocytes is characteristic of both AD and other neurodegenerative disorders, with some authors attributing a primary role to glial dysfunction in the pathogenesis of the disease

Understand that GLP-1 probiotics are dietary supplements regulated under the Dietary Supplement Health and Education Act (DSHEA)

It was approved in 2017 as a once-weekly blood sugar lowering drug (Ozempic), and in 2021 it shocked the world with its remarkable effects in the field of weight loss (Wegovy), evolving from a scientific concept into a benchmark drug that changes the treatment of metabolic diseases

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Anti-thyroid peroxidase (anti-TPO) antibodies are found in approximately 95% of patients, and anti-thyroglobulin (anti-Tg) antibodies are found in 6080%

Currently, there is no established causal link between Ozempic and increased blood clot risk according to MHRA and EMA guidance