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This explains the significant improvement in efficacy observed in TRIUMPH-4 (-28,7% at 68 weeks)

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[Accessed on 11 June 2026] Lillys oral GLP-1, orforglipron, demonstrated meaningful weight loss and cardiometabolic improvements in complete ATTAIN-1 results published in NEJM (2025)

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In addition, dopamine signalling has been found to influence microbiome colonization resistance against enteric pathogens and immunoregulation

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